Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case
Manar A. Abdul Aziz,
Mohamed A. Shawky,
Mohammed Atef
Issue:
Volume 4, Issue 2, December 2018
Pages:
31-35
Received:
28 August 2018
Accepted:
10 September 2018
Published:
10 October 2018
DOI:
10.11648/j.ijdm.20180402.11
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Abstract: Papillon–Lefèvre syndrome (PLS) is a rare genodermatosis caused by mutation in CTSC gene which is expressed in epithelial cells as well as in various immune cells including PMNs, macrophages, and their precursors. Such mutation results in palmoplantar hyperkeratosis, early onset periodontitis, susceptibility to infection and rarely mucocutaneous carcinomas. In this study, we aim to perform a systematic review on the incidence of oral squamous cell carcinoma in the association with Papillon-Lefevre syndrome and to introduce the first case report. An electronic search without date and language restrictions in three data bases, Pubmed, Cochrane Library, and Google Scholar in addition to a hand-searching were performed in August 2018. The review of the current literature revealed that such association has not been previously reported. We concluded that patients with Papillon-Lefevre syndrome are susceptible to develop different mucocutaneous carcinomas including OSCC.
Abstract: Papillon–Lefèvre syndrome (PLS) is a rare genodermatosis caused by mutation in CTSC gene which is expressed in epithelial cells as well as in various immune cells including PMNs, macrophages, and their precursors. Such mutation results in palmoplantar hyperkeratosis, early onset periodontitis, susceptibility to infection and rarely mucocutaneous ca...
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The First Permanent Molar Most Affected by Dental Caries - A Longitudinal Study
Canga Mimoza,
Malagnino Antonio Vito
Issue:
Volume 4, Issue 2, December 2018
Pages:
36-41
Received:
28 September 2018
Accepted:
12 October 2018
Published:
7 November 2018
DOI:
10.11648/j.ijdm.20180402.12
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Abstract: The cost effectiveness of this study was achieved within a two year time period, which confirmed that tooth number 26 is the most affected by caries. The relative effectiveness of this study are the observations done every 0-6-12-18-24 months. To identify, which of the teeth number 16, 26, 36 and 46 is affected more by caries within a two year time period in permanent dentition. The study only aimed at observing caries process, it had not any intention to intervene and show the effect of intervention. This is a longitudinal study, with a controlled sample for a period of 24 months. The present study included 488 children who were observed every 6 months in a 24 months’ time period. The population comes from a coastal city and the economic level had no significant deviations. The sample was chosen randomly. The data collected showed that tooth number 16 has been affected 37.62% by caries. Tooth number 26 has been affected 40.51% by caries. Tooth number 36 and 46 have been affected by dental caries 14.47% and 7.40%, respectively. This research proved that time 6-24 months influences more caries manifestation with a p-value=0.034, rather than the time 12-24 months which has a p=0.037. Based on, Anova test, the relation between groups of teeth and time is significant P<0.05. This study proved that tooth number 26 is the most affected by caries. First molars in the lower jaw have higher caries prevalence than the first molars in the upper jaw, this was another finding proved by the results obtained in this research. Clinical significance: The present study, which is performed in a two year time period with controls done every 6 months, proved that tooth number 26 is the most affected by dental caries.
Abstract: The cost effectiveness of this study was achieved within a two year time period, which confirmed that tooth number 26 is the most affected by caries. The relative effectiveness of this study are the observations done every 0-6-12-18-24 months. To identify, which of the teeth number 16, 26, 36 and 46 is affected more by caries within a two year time...
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